Osteosarcoma in the distal femur two years after an ipsilateral femoral shaft fracture. Most of the time, osteosarcoma begins in the hip or shin bones. Chondroblastomalike osteosarcoma is an exceedingly rare variant of osteosarcoma, with 22 cases reported in the englishlanguage literature. Total femoral reconstruction with custom prosthesis for.
Osteosarcoma of the femur with ossified peritoneal metastasis. Osteosarcoma in the distal femur two years after an. Pedicle frozen autograft for limb sparing surgery in a dog. Osteosarcoma also called osteogenic sarcoma is the most common type of cancer that starts in the bones. Osteosarcoma destroys local tissue and weakens the bone. This was treated conservatively and healed in weeks. Tratamiento del osteosarcoma e histiocitoma fibroso. A boy, aged 14 years, sustained a fracture of the midshaft of the femur. It is aggressive and most commonly occurs in children and young adults. Foto femur di samping menunjukkan area sklerotik yang ireguler pada daerah diametafiseal femur kiri. The distal femur and adjacent tibial plateau has been resected and a total knee replacement inserted.
Microscopically, the cartilage infiltrates the bone marrow, typically entrapping the preexisting trabeculae. Most vefinisi develop in the bones around the kneeeither in the distal femur the lower part of the thigh bone or the proximal tibia the upper part of the. Foto ap femur lima bulan kemudian setelah didiagnosis osteosarkoma. During the instruction phase, one of the doctors told me my right knee looked unusually swollen and sent me for an xray immediately. Tratamiento del osteosarcoma e histiocitoma fibroso maligno. Radiology pathological correlation of osteosarcoma in a tertiary care hospital a retrospective study p kannan1, m johnraj suresh2, heber anandan3 1professor and head, department of pathology, thoothukudi medical college, thoothukudi, tamil nadu, india, 2assistant professor. Distal femur osteotomy is done at the appropriate location as determined by the preoperative imaging studies fig 1. Distal femoral resection with endoprosthetic reconstruction martin malawer overview the distal femur figure 30. Primary osteosarcoma typically occurs in young patients 1020 years with 75% occurring before the age of 20. Osteosarcoma is a cancer that originates in bone tissue. Tampak lisis campuran dan sklerosis di dalam acetabulum dan ischium dengan massa jaringan lunak yang besar disertai mineralisasi yang tidak 14 baik. Osteosarcoma of the appendicular skeleton typically affects the metaphyseal regions of the proximal and distal tibia, distal femur, proximal humerus, and distal radius 1,2. The most common sites are the proximal humerus shoulder bone, the distal femur thigh bone, and the proximal tibia. Kagan, md careful study of 40 cases of osteosarcoma without evidence of multifocal dis ease, pulmonary metastasis, or history of exposure to predisposing factors has.
Osteosarcoma osa is the leading cause of death in retired racers. The pathological nature of the fracture is commonly recognized on the basis of radiological signs. In general, 3 to 4 cm beyond the point of proximal tumor extension is appropriate. Can cure in patients with osteosarcoma be achieved exclusively with chemotherapy and abrogation of surgery. After 10ish weeks of chemo, the treatment plan calls for a limb salvage surgery. Osteosarcoma of the hip in greyhounds couto veterinary. This is logical because the growth centers of the bone are more active during the puberty to adolescence time period. The most commonly involved bones are the metatarsus and tibia, followed by the femur.
Dec 30, 2015 18yearold female soccer player with new onset distal right thigh pain. Microscopically, the cartilage infiltrates the bone marrow, typically entrapping. Fractureassociated osteosarcoma of the femur in a cat. Since his tumour doesnt affect his entire femur, they will keep his hip joint and proximal upper femur in tact. Osteosarcoma discharge care care guide information en espanol. Pathological radiological signs are often evident by the time of diagnosis. Fatal pulmonary tumor embolism caused by chondroblastic. Feb 22, 2017 osteosarcoma is the most common primary bone maliganncy in the pediatric population. Osteosarcoma occurring in the jaws is rare, constituting only 6% to 7% of all osteosarcomas.
Osteosarcoma is a primary malignant bone tumor, which typically affects the metaphyseal growth plates in the femur, tibia, and humerus. Osteo boneosteoid tissue sarcoma malignant tumour of connective tissue 020412 dr. Osteosarcoma osteogenic sarcoma in children health. Mri of osteosarcoma of distal femur same patient roll over the images for more information. The aim of this study was to assess total femur replacement for the treatment of femoral osteosarcomas. After treatment get information about living well after osteosarcoma treatment and making decisions about next steps. Primary bone tumors are rare, accounting for osteosarcoma is the most frequent primary cancer of.
Everyone who has taken the course in radiologic pathology at the armed forces institute of pathology afip remembers bringing beautifully illustrated cases for accession to the institute. Osteossarcoma e o tumor osseo maligno primario mais comum. It is a procedure where the neurovascular structures and distal aspect of the limb leg are retained, and reattached to the proximal portion after the tumor has been removed. Specifically, it is an aggressive malignant neoplasm that arises from primitive transformed cells of mesenchymal origin and thus a sarcoma and that exhibits osteoblastic differentiation and produces malignant osteoid osteosarcoma is the most common histological form of primary bone cancer. While any of the bodys 206 bones can be affected, 50 percent of young patients have tumors near the knee. The other leading differential consideration is ewing. An osteosarcoma os or osteogenic sarcoma ogs or simply bone cancer is a cancerous tumor in a bone. Case discussion this case demonstrates relatively typical appearances of a bone forming osteosarcoma of the distal femur typical location in a 17yearold typical age.
The treating surgeon samples the bone marrow from the resection margin of the femur during definitive limb salvage surgery and finds microscopic evidence of tumor. We describe the case of a 58yearold caucasian man who. It has a bimodal distribution with peaks in the second decade of life and late. If you are facing osteosarcoma, we can help you learn about the treatment options and possible side effects, and point you to information and services to help in your cancer journey. This 65yearold woman first presented with a painful right knee mass of 2 months duration. Osteosarcoma is a malignant tumor that primarily affects the long bones but can also involve other bones in the body.
The patient had a workup that included an open biopsy, which was diagnosed as highgrade chondroblastic osteosarcoma. I joked with him that he was trying to trade service for service, but he wasnt joking. Although several case reports have been published on osteosarcoma of the femur, to the best of our knowledge this report is the first one with such an unusual clinical course. The term osteosarcoma as opposed to osteogenic sarcoma is preferred by the world health organization who. Common sites of involvement of osteosarcoma are the metaphyseal areas 91% of long bones of the extremities with its occurrence in descending order lower end of femur, upper end of tibia, upper end of humerus and upper end of femur. Recognition of osteosarcoma is based on the close relationship between the. Aug 23, 2018 the majority of tumors develop in the distal femur or the proximal tibia, the bones near the knee. Osteosarcoma is a type of bone cancer that most often affects children and teens. Triassic cancerosteosarcoma in a 240millionyearold. Tambien conocido como osteosarcoma clasico, comun, convencional. Patients usually have pain and swelling in the affected area. There is an infiltrative t1 hypointense, stir hyperintense, heterogeneously enhancing mass centered within the distal right.
E mais comum aos 20 anos e frequentemente tem crescimento rapido. The lesion is composed of multiple bloodfilled sinusoids, which can be. Classification, imaging, biopsy and staging of osteosarcoma. The patient subsequently underwent en bloc resection of the distal femur followed by amputation above the knee. Was it a pathological fracture or was it coincidence. Osteosarcoma types are dependent on degree of differentiation, location within the bone, and histological features. July, 2002 distal femur resection with endoprosthetic reconstruction 227 border and ligaments and menisci are removed. Can cure in patients with osteosarcoma be achieved. Renal metastases from osteosarcoma are extremely rare. It is the most common primary cancer of bone in children and adolescents.
Osteosarcoma is the most common postradiation malignant neoplasm occurring in the first 20 years following therapy for a solid cancer in childhood. Its common for active children and teenagers to experience limb pain. Pedicle frozen autograft for limb sparing surgery in a dog with femoral osteosarcoma. It can occur, very rarely, as a tumor of the soft tissues of the body, outside the bone itself. Osteosarcoma is the second most common primary malignant tumor of bone. Apr 10, 2018 after 10ish weeks of chemo, the treatment plan calls for a limb salvage surgery. There is associated irregular cortical destruction and an aggres. Osteosarcoma is very rare, but it is the most common type of bone cancer in children and teens.
Another common site is the proximal humerus, the bone near the shoulder. Osteosarcoma is a rare form of bone cancer that mostly affects children, adolescents, and young adults. Definisi osteosarkoma pdf osteosarcoma is the most common type of cancer that develops in bone. Characteristics and prognostic factors of osteosarcoma of the. It has a predilection for the knee area with 50% of cases in either the distal femur or proximal tibia, with the second most common site being the proximal humerus 10%. Radiation dose, chemotherapy and risk of osteosarcoma after solid tumours during childhood. Patients with osteosarcoma of the distal femur have traditionally been treated with a high aboveknee amputation. The tumor is slightly more common in males, with a broad age range from childhood to elderly. Osteosarcoma memorial sloan kettering cancer center. Best cases from the afip radiological society of north. Recognition of osteosarcoma is based on the close relationship. Only two tumors metastasized to the lungs one hemangiosarcoma and one osteosarcoma, and only three metastasized to a regional node two squamous cell carcinomas and one lympho sarcoma.
Jul 25, 2011 parosteal osteosarcoma is a welldifferentiated variant of osteosarcoma that affects the surface of the bone. We report a case of osteosarcoma in the distal femur diagnosed two years after an ipsilateral femoral shaft fracture. Parosteal osteosarcoma is a welldifferentiated variant of osteosarcoma that affects the surface of the bone. The cancer most often grows in the ends of long bones, especially the bottom of the thigh bone femur and the top of the larger shin bone tibia. Pdf on jan 1, 2016, shikha satish bhatt and others published osteosarcoma of mandible find, read and cite all the research you need on researchgate. The classic or socalled conventional osteosarcoma develops in the medullary cavity of the metaphysis of long bones. The large or giant dog breeds are those almost exclusively predisposed to the disease and the mean age of affected animals is. Best cases from the afip osteosarcoma of the femur with skip, lymph node, and lung metastases1 editors note. In dogs, metastasis is extremely common and can occur rapidly. Osteosarcoma following a fractured shaft of femur springerlink. A 19yearold man with a highgrade osteosarcoma of the femur. Radiology pathological correlation of osteosarcoma in a. That is when they will take most of his femur out, send it to pathology and they see how well his tumour has responded to the chemotherapy. Distal femur resection with endoprosthetic reconstruction.
These are examples of the gross pathology specimens of resected conventional osteosarcoma, consisting of both bony and soft tissue areas. Periosteal os is the second most common type of juxtacortical os, accounting for 1. Research open access total femoral reconstruction with custom prosthesis for osteosarcoma tang liu, xianghong zhang, qing zhang, xiangsheng zhang and xiaoning guo abstract background. Pdf osteosarcoma in the distal femur two years after an. In dogs the most commonly affected bones are the humerus upper arm, radiusulna forearm, femur thigh and tibia shin. This is a very frequent lesion which affects young individuals 1st decade. It can uncommonly occur in the diaphysis 9% figure 1a.
12 la tomografia computarizada se realiza para determinar. Learn more about the subtypes, causes, symptoms, diagnosis, treatment, and prognosis for osteosarcoma. Review of the literature suggests that osteosarcoma metastases of the kidneys usually exhibit aggressive behaviour with poor. Apr 28, 2014 rotationplasty compromise between amputation and limb salvage mc used for osteosarcoma of the distal femur in skeletally immature patients. Osteosarcoma is a malignant primary cancer of long bones. One year later an osteosarcoma developed at the site of the healed fracture. In 1879, gross published a paper entitled sarcoma of the long bone based upon a study of one hundred and sixtyfive cases.
Osteosarcoma is the commonest primary bone tumor in children and teenagers 1. It can however present as a lytic or mixed lyticsclerotic lesion. It typically affects patients in the 2nd or 3rd decade of life, with a characteristic location along the diaphyses of long bones fig 11, most commonly the tibia 18. The cancer cells in these tumors look like early forms of bone cells that normally help make new bone tissue, but the bone tissue in an osteosarcoma is not as strong as that of normal bones. The bones around the knee are the most commonly affected. Evidence of malignant osteoid bone andor cartilage formation with destructive lesions and sclerosis is characteristic of the disease. The duration of symptoms preceding a definitive diagnosis of osteosarcoma is quite long. We report two cases mimicking an osteochondroma, radiologically and histologically and propose an explanation. We present a case of a young male with osteosarcoma of the left femur who developed late recurrence in the form of large metastatic renal and pulmonary lesions. Mark gebhardt, md y kristy weber, md traducido al espanol por. It starts in immature bone cells that normally form new bone tissue. Intramedullary osteosarcoma pathology orthobullets. The xray showed a large tumor in my right distal femur.
1310 564 943 689 675 1413 1285 241 182 624 742 1123 408 69 129 268 1200 865 1059 122 1094 241 21 582 163 976 546 554 427 1259 1186 971 659 1192 1234 1102 1281 869 98 1398 349 645